NRO-1  

(a-b) NRO-1 stimulates release of GDNF             / GDNF enhances neurite elongation

(c) Elongation is inhibited by growth cone          inhibitor semaphorin 3A

(d) GDNF inhibits semaphorin 3A

AXON REGENERATION

MECHANISM OF ACTION

NRO-1: pathway for corneal neurite elongation

Cultured monkey trigeminal cells were triple-stained for neuronal filaments (red), glial cells (green), and nuclei (blue)