NRO-1
(a-b) NRO-1 stimulates release of GDNF / GDNF enhances neurite elongation
(c) Elongation is inhibited by growth cone inhibitor semaphorin 3A
(d) GDNF inhibits semaphorin 3A
AXON REGENERATION
MECHANISM OF ACTION
NRO-1: pathway for corneal neurite elongation
Cultured monkey trigeminal cells were triple-stained for neuronal filaments (red), glial cells (green), and nuclei (blue)