A Novel
Regenerative Treatment
NRO-1 is a topically delivered, nerve regenerative therapeutic that accelerates nerve regeneration and recovery of functional nerves
Corneal Nerve Degeneration

Retinal Ganglion Cell Degeneration

NRO-1 MOA
NRO-1 releases glial cell-derived neurotrophic factor (GDNF), which recovers ocular surface function through regenerating corneal nerves and accelerating corneal wound healing directly
Corneal Sensitivity Recovery
Corneal Nerve Regeneration
Corneal Epithelium Migration
Corneal Wound Healing
Based on the results from the Phase 1 SAD and MAD clinical studies, a Phase 2 clinical study of NRO-1 in dry eye disease was initiated in the January 2020.
NRO-1 has shown efficacy in a range of nonclinical studies
Nerve damage is linked to a range of ophthalmic diseases, including dry eye disease, creating a high probability of success for human studies
Phase 2
Dry Eye Disease:
Phase 1
Clinical Study:
Well tolerated across the entire dose range, all patients completed dosing in both the SAD and MAD studies.
Study Overview:
Multicenter, randomized, double-asked, vehicle-controlled clinical trial that will evaluate the safety and efficacy of NRO-1in patients with dry eyed disease
120 patients with moderate-to-severe drye disease, including post-surgical patients.
2 dosages of NRO-1 compared to
vehicle (placebo)
Study initiated in Janary 2020, with results available in 2H 2020
Key Results:
Similar safety and tolerability to placebo
No serious or severe adverse events
No clinical chemistry, hematology or ECG safety concerns
Safety profile consistent with preclinical data and supportive of continuing to Phase 2