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There are over 8 million ocular surgeries per year in the U.S.
Laser-assisted in situ keratomileusis (LASIK)
~1 million
refractive surgeries annually 
LASIK surgery is the most commonly performed refractive surgery   
LASIK is an effective treatment for low, moderate, and high myopia with and without astigmatism, as well as hyperopia with and without astigmatism.  LASIK is an outpatient surgery performed with topical anesthesia. 
~4 million
cataract surgeries annually 
Cataracts is primarily related to the degenerative effects of aging on cell structure
Cataract surgery is a painless, progressive process that is highly variable among individuals. Patients usually present with bilateral symptoms and complain of difficulty with night driving (especially due to glare of oncoming headlights) or reading fine print.  Surgery, the only treatment, is prescribed if symptoms interfere with the patient's ability to meet their needs of daily living. 

During various types of ophthalmic surgeries, corneal nerves are damaged by the incision of the cornea.  Surgeries can lead to morphological changes of corneal nerves with corneal denervation, including decreased corneal sensitivity, resulting in:


1. Significant reductions in corneal subbasal nerve fiber density and nerve branching and decreased  corneal sensitivity are reported in transplanted cornea

2. Decreased corneal sensitivity

3. Morphological changes of nerves and/or decreased sensitivity are also reported in cornea undergoing  myopic and hyperopic surgeries

4. Dry eye is the number one patient complaint in corneal refractive surgery and occurs to some degree in virtually every corneal refractive surgery patient

U.S. Phase 2 post-LASIK Care Study Planned for 2020 

Post Surgical 

Corneal Sensitivity

We believe NRO-1 promotes the innervation of de-nerved corneas that are damaged after ophthalmic surgery.  In addition, the pathological conditions of ocular surface caused by corneal denervation may be improved by corneal reinnervation.  There is an unmet need for a therapy that has nerve fiber regeneration activity which enhances healing and reduces the time to resolution of decreased corneal sensitivity after surgery. 


  • Less discomfort

  • Reduced need for post-operative artificial tear drops

  • Reduced complications such as    corneal scarring, infection, and residual refractive error

  • Improvement in basal tear production

  • Faster visual recovery

  • Better vision

NRO-1 may improve corneal sensation following surgery,     leading to:

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