Post Surgery | Neuroptika

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POST SURGICAL RECOVERY

There are over 8 million ocular surgeries per year in the U.S.

LASIK SURGERY

Laser-assisted in situ keratomileusis (LASIK)

~1 million

refractive surgeries annually

LASIK surgery is the most commonly performed refractive surgery

LASIK is an effective treatment for low, moderate, and high myopia with and without astigmatism, as well as hyperopia with and without astigmatism. LASIK is an outpatient surgery performed with topical anesthesia.

~4 million

cataract surgeries annually

Cataracts is primarily related to the degenerative effects of aging on cell structure

Cataract surgery is a painless, progressive process that is highly variable among individuals. Patients usually present with bilateral symptoms and complain of difficulty with night driving (especially due to glare of oncoming headlights) or reading fine print. Surgery, the only treatment, is prescribed if symptoms interfere with the patient's ability to meet their needs of daily living.

CATARACT SURGERY

OPHTHALMIC SURGERY

During various types of ophthalmic surgeries, corneal nerves are damaged by the incision of the cornea. Surgeries can lead to morphological changes of corneal nerves with corneal denervation, including decreased corneal sensitivity, resulting in:

1. Significant reductions in corneal subbasal nerve fiber density and nerve branching and decreased corneal sensitivity are reported in transplanted cornea

2. Decreased corneal sensitivity

3. Morphological changes of nerves and/or decreased sensitivity are also reported in cornea undergoing myopic and hyperopic surgeries

4. Dry eye is the number one patient complaint in corneal refractive surgery and occurs to some degree in virtually every corneal refractive surgery patient

U.S. Phase 2 post-LASIK Care Study Planned for 2020

Post Surgical

Corneal Sensitivity

We believe NRO-1 promotes the innervation of de-nerved corneas that are damaged after ophthalmic surgery. In addition, the pathological conditions of ocular surface caused by corneal denervation may be improved by corneal reinnervation. There is an unmet need for a therapy that has nerve fiber regeneration activity which enhances healing and reduces the time to resolution of decreased corneal sensitivity after surgery.

Less discomfort

Reduced need for post-operative artificial tear drops

Reduced complications such as corneal scarring, infection, and residual refractive error

Improvement in basal tear production

Faster visual recovery

Better vision

NRO-1 may improve corneal sensation following surgery, leading to: